USA begins study on allergic reactions due to Pfizer & Moderna Covid vaccines
Several allergic reaction incidents, including serious episodes, known as anaphylaxis, have been reported in the US after vaccinations of Pfizer/BioNTech and Moderna shots.
The US National Institutes of Health said on Wednesday it had begun a mid-stage study to determine the risk of allergic reactions to COVID-19 vaccines made by Moderna Inc and Pfizer Inc.
A clinical trial is underway to determine whether people who are highly allergic or have a mast cell disorder are at increased risk for an immediate and systemic allergic reaction to the Moderna or Pfizer-BioNTech Covid-19 vaccines.
If a significant number of systemic allergic reactions to either or both vaccines occur during the trial, investigators will analyse these biological samples to examine possible mechanisms for the reactions and whether certain genetic patterns are associated with higher risk.
The Moderna and Pfizer-BioNTech COVID-19 vaccines are the first two COVID-19 vaccines authorized by the Food and Drug Administration for emergency use and already have been given to millions of Americans. Most of the rare, severe allergic reactions to these vaccines have occurred in people with a history of allergies. A substantial number of these people had previously experienced a life-threatening allergic reaction called anaphylaxis.